The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

The cryo-EM structure of monoclonal antibody aE11 bound to polyC9 reveals that the binding site within the Membrane Attack Complex is a quaternary discontinuous epitope formed by two separate surfaces of the oligomeric C9 periphery.

Bibliographic Details
Main Authors: Charles Bayly-Jones, Bill H. T. Ho, Corinna Lau, Eleanor W. W. Leung, Laura D’Andrea, Christopher J. Lupton, Susan M. Ekkel, Hariprasad Venugopal, James C. Whisstock, Tom E. Mollnes, Bradley A. Spicer, Michelle A. Dunstone
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04431-y

Internet

https://doi.org/10.1038/s42003-023-04431-y

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