In vitro enhancement of Zika virus infection by preexisting West Nile virus antibodies in human plasma-derived immunoglobulins revealed after P2 binding site-specific enrichment

In vitro enhancement of Zika virus infection by preexisting West Nile virus antibodies in human plasma-derived immunoglobulins revealed after P2 binding site-specific enrichment

ABSTRACT Human immunoglobulin preparations contain a diverse range of polyclonal antibodies that reflect past immune responses against pathogens encountered by the blood donor population. In this study, we examined a panel of intravenous immunoglobulins (IGIVs) manufactured over the past two decades...

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Bibliographic Details
Main Authors: Yong He, Lilin Zhong, Hailing Yan, Maria Luisa Virata, Lu Deng, Ashish K. Mishra, Evi Struble, Dorothy Scott, Pei Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2024-06-01
Series:Microbiology Spectrum
Subjects:
intravenous immunoglobulin (IGIV)
Zika virus
anti-WNV antibodies
cross-reactive antibodies
antibody-dependent enhancement (ADE)
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00758-24

Internet

https://journals.asm.org/doi/10.1128/spectrum.00758-24

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