An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium
Background Peanut allergy is a frequent cause of food allergy and potentially life‐threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus no...
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | https://doi.org/10.1002/clt2.12197 |
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| author | Margitta Worm Aikaterina Alexiou Veronika Höfer Till Birkner Alexander C. S. N. Jeanrenaud Florent Fauchère Kristijan Pazur Carolin Steinert Aleix Arnau‐Soler Priyanka Banerjee Andreas Diefenbach Josefine Dobbertin‐Welsch Sabine Dölle‐Bierke Wojciech Francuzik Ahla Ghauri Stephanie Heller Birgit Kalb Ulrike Löber Ingo Marenholz Lajos Markó Jörg Scheffel Olena Potapenko Stephanie Roll Susanne Lau Young‐Ae Lee Julian Braun Andreas Thiel Magda Babina Sabine Altrichter Sofia Kirke Forslund Kirsten Beyer |
| author_facet | Margitta Worm Aikaterina Alexiou Veronika Höfer Till Birkner Alexander C. S. N. Jeanrenaud Florent Fauchère Kristijan Pazur Carolin Steinert Aleix Arnau‐Soler Priyanka Banerjee Andreas Diefenbach Josefine Dobbertin‐Welsch Sabine Dölle‐Bierke Wojciech Francuzik Ahla Ghauri Stephanie Heller Birgit Kalb Ulrike Löber Ingo Marenholz Lajos Markó Jörg Scheffel Olena Potapenko Stephanie Roll Susanne Lau Young‐Ae Lee Julian Braun Andreas Thiel Magda Babina Sabine Altrichter Sofia Kirke Forslund Kirsten Beyer |
| author_sort | Margitta Worm |
| collection | DOAJ |
| description | Background Peanut allergy is a frequent cause of food allergy and potentially life‐threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non‐allergic controls. Methods Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen‐reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results We identified combined cellular and soluble biomarker signatures that stratify donors into peanut‐allergic and non‐allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies. |
| first_indexed | 2024-04-13T15:42:19Z |
| format | Article |
| id | doaj.art-96f3584ce15843fb9adf0584fa7d5bc7 |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-04-13T15:42:19Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-96f3584ce15843fb9adf0584fa7d5bc72022-12-22T02:41:07ZengWileyClinical and Translational Allergy2045-70222022-10-011210n/an/a10.1002/clt2.12197An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortiumMargitta Worm0Aikaterina Alexiou1Veronika Höfer2Till Birkner3Alexander C. S. N. Jeanrenaud4Florent Fauchère5Kristijan Pazur6Carolin Steinert7Aleix Arnau‐Soler8Priyanka Banerjee9Andreas Diefenbach10Josefine Dobbertin‐Welsch11Sabine Dölle‐Bierke12Wojciech Francuzik13Ahla Ghauri14Stephanie Heller15Birgit Kalb16Ulrike Löber17Ingo Marenholz18Lajos Markó19Jörg Scheffel20Olena Potapenko21Stephanie Roll22Susanne Lau23Young‐Ae Lee24Julian Braun25Andreas Thiel26Magda Babina27Sabine Altrichter28Sofia Kirke Forslund29Kirsten Beyer30Division of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyDivision of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyDivision of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyExperimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin GermanyMax Delbrück Center for Molecular Medicine Helmholtz Association Berlin GermanySi‐M/“Der Simulierte Mensch” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin Berlin GermanyDivision of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyInstitute of Allergology IFA Charité‐Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin GermanyMax Delbrück Center for Molecular Medicine Helmholtz Association Berlin GermanyInstitute of Physiology Charité – Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin GermanyMucosal and Developmental Immunology German Rheuma Research Center Berlin (DRFZ) Berlin GermanyDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyDivision of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyDivision of Allergy and Immunology Department of Dermatology, Venerology and Allergy Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyMax Delbrück Center for Molecular Medicine Helmholtz Association Berlin GermanyDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyExperimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin GermanyMax Delbrück Center for Molecular Medicine Helmholtz Association Berlin GermanyExperimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin GermanyInstitute of Allergology IFA Charité‐Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin GermanyExperimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin GermanyInstitute of Social Medicine, Epidemiology and Health Economics Charité—Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyMax Delbrück Center for Molecular Medicine Helmholtz Association Berlin GermanySi‐M/“Der Simulierte Mensch” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin Berlin GermanySi‐M/“Der Simulierte Mensch” a Science Framework of Technische Universität Berlin and Charité – Universitätsmedizin Berlin Berlin GermanyInstitute of Allergology IFA Charité‐Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin GermanyInstitute of Allergology IFA Charité‐Universitätsmedizin Berlin Freie Universität Berlin Humboldt‐Universität zu Berlin Berlin Institute of Health Berlin GermanyExperimental and Clinical Research Center A Cooperation of Charité‐Universitätsmedizin Berlin Max Delbrück Center for Molecular Medicine Berlin GermanyDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine Charité – Universitätsmedizin Berlin Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin GermanyBackground Peanut allergy is a frequent cause of food allergy and potentially life‐threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non‐allergic controls. Methods Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen‐reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. Results We identified combined cellular and soluble biomarker signatures that stratify donors into peanut‐allergic and non‐allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. Conclusion By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.https://doi.org/10.1002/clt2.12197biomarkerepigeneticsfood allergymicrobiomepeanut allergy |
| spellingShingle | Margitta Worm Aikaterina Alexiou Veronika Höfer Till Birkner Alexander C. S. N. Jeanrenaud Florent Fauchère Kristijan Pazur Carolin Steinert Aleix Arnau‐Soler Priyanka Banerjee Andreas Diefenbach Josefine Dobbertin‐Welsch Sabine Dölle‐Bierke Wojciech Francuzik Ahla Ghauri Stephanie Heller Birgit Kalb Ulrike Löber Ingo Marenholz Lajos Markó Jörg Scheffel Olena Potapenko Stephanie Roll Susanne Lau Young‐Ae Lee Julian Braun Andreas Thiel Magda Babina Sabine Altrichter Sofia Kirke Forslund Kirsten Beyer An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium Clinical and Translational Allergy biomarker epigenetics food allergy microbiome peanut allergy |
| title | An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium |
| title_full | An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium |
| title_fullStr | An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium |
| title_full_unstemmed | An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium |
| title_short | An interdisciplinary approach to characterize peanut‐allergic patients—First data from the FOOD@ consortium |
| title_sort | interdisciplinary approach to characterize peanut allergic patients first data from the food consortium |
| topic | biomarker epigenetics food allergy microbiome peanut allergy |
| url | https://doi.org/10.1002/clt2.12197 |
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