Caspofungin-induced β(1,3)-glucan exposure in Candida albicans is driven by increased chitin levels

Caspofungin-induced β(1,3)-glucan exposure in Candida albicans is driven by increased chitin levels

ABSTRACT To successfully induce disease, Candida albicans must effectively evade the host immune system. One mechanism used by C. albicans to achieve this is to mask immunogenic β(1,3)-glucan epitopes within its cell wall under an outer layer of mannosylated glycoproteins. Consequently, induction of...

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Bibliographic Details
Main Authors: Andrew S. Wagner, Stephen W. Lumsdaine, Mikayla M. Mangrum, Todd B. Reynolds
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
Candida albicans
caspofungin
chitin
β-glucan
unmasking
Online Access:https://journals.asm.org/doi/10.1128/mbio.00074-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00074-23

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