N-Glycosylation at Asn291 Stabilizes TIM-4 and Promotes the Metastasis of NSCLC

N-Glycosylation at Asn291 Stabilizes TIM-4 and Promotes the Metastasis of NSCLC

T-cell immunoglobulin domain and mucin domain 4 (TIM-4) is a transmembrane protein that promotes epithelial-mesenchymal transition (EMT), migration and invasion of non-small cell lung cancer (NSCLC) cells. Most transmembrane proteins are modified by N-glycosylation and the importance of protein N-gl...

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Bibliographic Details
Main Authors: Siyuan Chen, Yuzhen Wang, Wen Liu, Yan Liang, Yingchun Wang, Zhuanchang Wu, Liyun Xu, Xiaohong Liang, Chunhong Ma, Lifen Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
NSCLC
TIM-4
N-glycosylation
metastasis
stability
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.730530/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.730530/full

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