FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells

FilGAP, a GAP for Rac1, down-regulates invadopodia formation in breast cancer cells

Invadopodia are protrusive structures that mediate the extracellular matrix (ECM) degradation required for tumor invasion and metastasis. Rho small GTPases regulate invadopodia formation, but the molecular mechanisms of how Rho small GTPase activities are regulated at the invadopodia remain unclear....

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Bibliographic Details
Main Authors: Koji Saito, Sakino Ozawa, Yosuke Chiba, Ruri Takahashi, Ryoya Ogomori, Kojiro Mukai, Tomohiko Taguchi, Hiroyasu Hatakeyama, Yasutaka Ohta
Format: Article
Language:English
Published: Japan Society for Cell Biology 2023-07-01
Series:Cell Structure and Function
Subjects:
invadopodia
breast carcinoma
rac1
filgap
pi(3,4)p2
Online Access:https://www.jstage.jst.go.jp/article/csf/48/2/48_23032/_html/-char/en

Internet

https://www.jstage.jst.go.jp/article/csf/48/2/48_23032/_html/-char/en

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