Murine Glut-1 transporter haploinsufficiency: Postnatal deceleration of brain weight and reactive astrocytosis

Murine Glut-1 transporter haploinsufficiency: Postnatal deceleration of brain weight and reactive astrocytosis

Glucose transporter type 1 (Glut-1) facilitates glucose flux across the blood–brain-barrier. In humans, Glut-1 deficiency causes acquired microcephaly, seizures and ataxia, which are recapitulated in our Glut-1 haploinsufficient mouse model. Postnatal brain weight deceleration and development of rea...

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Bibliographic Details
Main Authors: Paivi M. Ullner, Alessia Di Nardo, James E. Goldman, Scott Schobel, Hong Yang, Kristin Engelstad, Dong Wang, Mustafa Sahin, Darryl C. De Vivo
Format: Article
Language:English
Published: Elsevier 2009-10-01
Series:Neurobiology of Disease
Subjects:
Glut-1 deficiency mouse model
Brain development
Microcephaly
Apoptosis
Proliferation
Astrogliosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001648

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http://www.sciencedirect.com/science/article/pii/S0969996109001648

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