A Novel Statin Compound from Monacolin J Produced Using CYP102A1-Catalyzed Regioselective C-Hydroxylation

A Novel Statin Compound from Monacolin J Produced Using CYP102A1-Catalyzed Regioselective C-Hydroxylation

Statins inhibit the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), which is the rate-limiting enzyme in cholesterol biosynthesis. Statin therapy reduces morbidity and mortality in those who are at high risk of cardiovascular disease. Monacolin J is a statin compound, which is...

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Bibliographic Details
Main Authors: Ngoc Tan Cao, Ngoc Anh Nguyen, Chan Mi Park, Gun Su Cha, Ki Deok Park, Chul-Ho Yun
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceuticals
Subjects:
monacolin J
human liver microsomes
statin
HMG-CoA reductase
regioselective hydroxylation
Online Access:https://www.mdpi.com/1424-8247/14/10/981

Internet

https://www.mdpi.com/1424-8247/14/10/981

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