Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain

Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain

Jingzhaotoxin-34 (JZTX-34) is a selective inhibitor of tetrodotoxin-sensitive (TTX-S) sodium channels. In this study, we found that JZTX-34 selectively acted on Nav1.7 with little effect on other sodium channel subtypes including Nav1.5. If the DIIS3-S4 linker of Nav1.5 is substituted by the corresp...

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Bibliographic Details
Main Authors: Xiongzhi Zeng, Pengpeng Li, Bo Chen, Juan Huang, Ren Lai, Jingze Liu, Mingqiang Rong
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Toxins
Subjects:
peptide toxin
sodium channels
Nav1.7
pain
Online Access:http://www.mdpi.com/2072-6651/10/2/64

Internet

http://www.mdpi.com/2072-6651/10/2/64

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