Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Dengue virus (DENV) threatens almost 70% of the world’s population, with no effective vaccine or therapeutic currently available. A key contributor to infection is nuclear localisation in the infected cell of DENV nonstructural protein 5 (NS5) through the action of the host importin (IMP)...

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Bibliographic Details
Main Authors: Sundy N. Y. Yang, Sarah C. Atkinson, Johanna E. Fraser, Chunxiao Wang, Belinda Maher, Noelia Roman, Jade K. Forwood, Kylie M. Wagstaff, Natalie A. Borg, David A. Jans
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
flavivirus
nuclear transport inhibitors
importins
viral infection
dengue virus
Online Access:https://www.mdpi.com/2073-4409/8/3/281

Internet

https://www.mdpi.com/2073-4409/8/3/281

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