An Expanded Role for HLA Genes: HLA-B Encodes a microRNA that Regulates IgA and Other Immune Response Transcripts
We describe a novel functional role for the HLA-B locus mediated by its intron-encoded microRNA (miRNA), miR-6891-5p. We show that in vitro inhibition of miR-6891-5p impacts the expression of nearly 200 transcripts within the B-lymphoblastoid cell line (B-LCL) COX, affecting a large number of metabo...
| Auteurs principaux: | , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Frontiers Media S.A.
2017-05-01
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| Collection: | Frontiers in Immunology |
| Sujets: | |
| Accès en ligne: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00583/full |