p53-stabilizing Agent CP-31398 Prevents Growth and Invasion of Urothelial Cancer of the Bladder in Transgenic UPII-SV40T Mice

p53-stabilizing Agent CP-31398 Prevents Growth and Invasion of Urothelial Cancer of the Bladder in Transgenic UPII-SV40T Mice

The high prevalence of bladder cancer and its recurrence make it an important target for chemoprevention. About half of invasive urothelial tumors have mutations in p53. We determined the chemopreventive efficacy of a p53-stabilizing agent, CP-31398, in a transgenic UPII-SV40T mouse model of bladder...

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Bibliographic Details
Main Authors: Venkateshwar Madka, Yuting Zhang, Qian Li, Altaf Mohammed, Puneet Sindhwani, Stan Lightfoot, Xue-Re Wu, Levy Kopelovich, Chinthalapally V Rao
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613801005

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http://www.sciencedirect.com/science/article/pii/S1476558613801005

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