Repetitive Exposure to Bacteriophage Cocktails against <i>Pseudomonas aeruginosa</i> or <i>Escherichia coli</i> Provokes Marginal Humoral Immunity in Naïve Mice

Repetitive Exposure to Bacteriophage Cocktails against <i>Pseudomonas aeruginosa</i> or <i>Escherichia coli</i> Provokes Marginal Humoral Immunity in Naïve Mice

Phage therapy of ventilator-associated pneumonia (VAP) is of great interest due to the rising incidence of multidrug-resistant bacterial pathogens. However, natural or therapy-induced immunity against therapeutic phages remains a potential concern. In this study, we investigated the innate and adapt...

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Bibliographic Details
Main Authors: Chantal Weissfuss, Sandra-Maria Wienhold, Magdalena Bürkle, Baptiste Gaborieau, Judith Bushe, Ulrike Behrendt, Romina Bischoff, Imke H. E. Korf, Sarah Wienecke, Antonia Dannheim, Holger Ziehr, Christine Rohde, Achim D. Gruber, Jean-Damien Ricard, Laurent Debarbieux, Martin Witzenrath, Geraldine Nouailles
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
phage therapy
immunogenicity
adaptive and innate immunity
pneumonia
Online Access:https://www.mdpi.com/1999-4915/15/2/387

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https://www.mdpi.com/1999-4915/15/2/387

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