Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development

Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development

Resistant mouse strains mount a protective T cell-mediated immune response upon infection with Leishmania (L.) parasites. Healing correlates with a T helper (Th) cell-type 1 response characterized by a pronounced IFN-γ production, while susceptibility is associated with an IL-4-dependent Th2-type re...

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Bibliographic Details
Main Authors: Nicole Zimara, Menberework Chanyalew, Abraham Aseffa, Ger van Zandbergen, Bernd Lepenies, Maximilian Schmid, Richard Weiss, Anne Rascle, Anja Kathrin Wege, Jonathan Jantsch, Valentin Schatz, Gordon D. Brown, Uwe Ritter
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
Curdlan
β-glucan
Dectin-1
cutaneous leishmaniasis
adaptive immunity
dendritic cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00263/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00263/full

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