IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these isotypes are presumed to be redundant, it is unknown how this could impose tolerance. We introduced th...

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Bibliographic Details
Main Authors: Mark Noviski, James L Mueller, Anne Satterthwaite, Lee Ann Garrett-Sinha, Frank Brombacher, Julie Zikherman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
B cell receptor
IgM
IgD
autoimmune response/disease
signal transduction
antibody responses
Online Access:https://elifesciences.org/articles/35074

Internet

https://elifesciences.org/articles/35074

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