Use of In Vitro Dynamic Colon Model (DCM) to Inform a Physiologically Based Biopharmaceutic Model (PBBM) to Predict the In Vivo Performance of a Modified-Release Formulation of Theophylline

Use of In Vitro Dynamic Colon Model (DCM) to Inform a Physiologically Based Biopharmaceutic Model (PBBM) to Predict the In Vivo Performance of a Modified-Release Formulation of Theophylline

A physiologically based biopharmaceutic model (PBBM) of a modified-release formulation of theophylline (Uniphyllin Continus<sup>®</sup> 200 mg tablet) was developed and implemented to predict the pharmacokinetic (PK) data of healthy male volunteers by integrating dissolution profiles mea...

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Bibliographic Details
Main Authors: Konstantinos Stamatopoulos, Connor O’Farrell, Mark J. H. Simmons, Hannah K. Batchelor, Nena Mistry
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
PBBM
PBPK
Dynamic Colon Model (DCM)
SimCyp<sup>®</sup>
in vitro model
dissolution testing
Online Access:https://www.mdpi.com/1999-4923/15/3/882

Internet

https://www.mdpi.com/1999-4923/15/3/882

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