Actions of FTY720 (Fingolimod), a Sphingosine-1-Phosphate Receptor Modulator, on Delayed-Rectifier K<sup>+</sup> Current and Intermediate-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel in Jurkat T-Lymphocytes

Actions of FTY720 (Fingolimod), a Sphingosine-1-Phosphate Receptor Modulator, on Delayed-Rectifier K<sup>+</sup> Current and Intermediate-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channel in Jurkat T-Lymphocytes

FTY720 (fingolimod), a modulator of sphingosine-1-phosphate receptors, is known to produce the immunomodulatory actions and to be beneficial for treating the relapsing multiple sclerosis. However, whether it exerts any effects on membrane ion currents in immune cells remains largely unknown. Herein,...

Full description

Bibliographic Details
Main Authors: Wei-Ting Chang, Ping-Yen Liu, Sheng-Nan Wu
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
FTY720
lymphocytes
delayed-rectifier K<sup>+</sup> current
inactivation kinetics
intermediate-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel
Online Access:https://www.mdpi.com/1420-3049/25/19/4525

Internet

https://www.mdpi.com/1420-3049/25/19/4525

Similar Items