Natural Compounds Tapinarof and Galactomyces Ferment Filtrate Downregulate IL-33 Expression via the AHR/IL-37 Axis in Human Keratinocytes

Natural Compounds Tapinarof and Galactomyces Ferment Filtrate Downregulate IL-33 Expression via the AHR/IL-37 Axis in Human Keratinocytes

Interleukin (IL)-37 suppresses systemic and local inflammation. It is expressed in the epidermis, the external layer of the skin, and is decreased in inflammatory skin diseases including atopic dermatitis (AD) and psoriasis. Therefore, an agent applied topically on the skin that can increase IL-37 c...

Full description

Bibliographic Details
Main Authors: Gaku Tsuji, Akiko Hashimoto-Hachiya, Tomoyo Matsuda-Taniguchi, Ayako Takai-Yumine, Masaki Takemura, Xianghong Yan, Masutaka Furue, Takeshi Nakahara
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
IL-33
AHR (aryl hydrocarbon receptor)
IL-37
atopic dermatitis
psoriasis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.745997/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.745997/full

Similar Items