A MBD-seq protocol for large-scale methylome-wide studies with (very) low amounts of DNA

A MBD-seq protocol for large-scale methylome-wide studies with (very) low amounts of DNA

We recently showed that, after optimization, our methyl-CpG binding domain sequencing (MBD-seq) application approximates the methylome-wide coverage obtained with whole-genome bisulfite sequencing (WGB-seq), but at a cost that enables adequately powered large-scale association studies. A prior drawb...

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Bibliographic Details
Main Authors: Karolina A. Aberg, Robin F. Chan, Andrey A. Shabalin, Min Zhao, Gustavo Turecki, Nicklas Heine Staunstrup, Anna Starnawska, Ole Mors, Lin Y. Xie, Edwin JCG van den Oord
Format: Article
Language:English
Published: Taylor & Francis Group 2017-09-01
Series:Epigenetics
Subjects:
blood spots
lab-technical optimization
low-input dna
methyl-cpg binding domain sequencing
methylome-wide association study
methylome-wide coverage
whole-genome bisulfite sequencing
Online Access:http://dx.doi.org/10.1080/15592294.2017.1335849

Internet

http://dx.doi.org/10.1080/15592294.2017.1335849

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