The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers

The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers

Abstract Background Invariant chain (CD74, Ii) is a multifunctional protein expressed in antigen presenting cells. It assists the ER exit of various cargos and serves as a receptor for the macrophage migration inhibitory factor. The newly translated Ii chains trimerize, a structural feature that is...

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Bibliographic Details
Main Authors: Maryse Cloutier, Jean-Simon Fortin, Jacques Thibodeau
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Immunology
Subjects:
Antigen presentation
MHCII
CD74
Nonamerization
Transmembrane domain
Trimerization domain
Online Access:https://doi.org/10.1186/s12865-021-00444-6

Internet

https://doi.org/10.1186/s12865-021-00444-6

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