Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states

Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states

Abstract Vascular risk factors such as chronic hypertension are well-established major modifiable factors for the development of cerebral small vessel disease (cSVD). In the present study, our focus was the investigation of cSVD-related phenotypic changes in microglia in human disease and in the spo...

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Main Authors: Lorena Morton, Philipp Arndt, Alejandra P. Garza, Solveig Henneicke, Hendrik Mattern, Marilyn Gonzalez, Alexander Dityatev, Deniz Yilmazer-Hanke, Stefanie Schreiber, Ildiko R. Dunay
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Acta Neuropathologica Communications
Subjects:
Chronic arterial hypertension
Cerebral small vessel disease (cSVD)
Microglia
Spontaneously hypertensive stroke-prone rat (SHRSP)
Online Access:https://doi.org/10.1186/s40478-023-01672-0

Internet

https://doi.org/10.1186/s40478-023-01672-0

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