Analysis of the Dissolution Mechanism of Drugs into Polymers: The Case of the PVP/Sulindac System

This paper is dealing with the dissolution mechanism of crystalline sulindac into amorphous Polyvinylpyrrolidone (PVP) upon heating and annealing at high temperatures. Special attention is paid on the diffusion mechanism of drug molecules in the polymer which leads to a homogeneous amorphous solid d...

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Bibliographic Details
Main Authors: Mansour Latreche, Jean-François Willart
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/15/5/1505