Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes.

Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes.

TRPV4 channels are calcium-permeable cation channels that are activated by several physicochemical stimuli. Accordingly, TRPV4 channels have been implicated in the regulation of osmosensing, mechanotransduction, thermosensation, and epithelial/endothelial barrier functions. Whether TRPV4 is also mec...

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Bibliographic Details
Main Authors: Aida Olivan-Viguera, Angel Luis Garcia-Otin, Javier Lozano-Gerona, Edgar Abarca-Lachen, Ana J Garcia-Malinis, Kirk L Hamilton, Yolanda Gilaberte, Esther Pueyo, Ralf Köhler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5749757?pdf=render

Internet

http://europepmc.org/articles/PMC5749757?pdf=render

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