A variability in response of osteoclasts to zoledronic acid is mediated by smoking-associated modification in the DNA methylome

A variability in response of osteoclasts to zoledronic acid is mediated by smoking-associated modification in the DNA methylome

Abstract Background Clinical trials have shown zoledronic acid as a potent bisphosphonate in preventing bone loss, but with varying potency between patients. Human osteoclasts ex vivo reportedly displayed a variable sensitivity to zoledronic acid > 200-fold, determined by the half-maximal inhibit...

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Bibliographic Details
Main Authors: Qihua Tan, Anaïs Marie Julie Møller, Chuan Qiu, Jonna Skov Madsen, Hui Shen, Troels Bechmann, Jean-Marie Delaisse, Bjarne Winther Kristensen, Hong-Wen Deng, David Karasik, Kent Søe
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Clinical Epigenetics
Subjects:
Osteoclasts
Antiresorptives
Zoledronic acid
Epigenetics
DNA methylation
Association studies
Online Access:https://doi.org/10.1186/s13148-023-01449-1

Internet

https://doi.org/10.1186/s13148-023-01449-1

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