A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.

A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein.

Colicins are protein antibiotics synthesised by Escherichia coli strains to target and kill related bacteria. To prevent host suicide, colicins are inactivated by binding to immunity proteins. Despite their high avidity (K(d) ≈ fM, lifetime ≈ 4 days), immunity protein release is a pre-requisite of c...

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Détails bibliographiques
Auteurs principaux: Oliver E Farrance, Eleanore Hann, Renata Kaminska, Nicholas G Housden, Sasha R Derrington, Colin Kleanthous, Sheena E Radford, David J Brockwell
Format: Article
Langue:English
Publié: Public Library of Science (PLoS) 2013-01-01
Collection:PLoS Biology
Accès en ligne:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23431269/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23431269/?tool=EBI

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