Group A streptococcal M-protein specific antibodies and T-cells drive the pathology observed in the rat autoimmune valvulitis model

Group A streptococcal M-protein specific antibodies and T-cells drive the pathology observed in the rat autoimmune valvulitis model

Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are autoimmune mediated diseases triggered by group A streptococcal (GAS) infections. Molecular mimicry between GAS M-proteins and host tissue proteins has been proposed as the mechanism that initiates autoreactive immune responses in ARF...

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Bibliographic Details
Main Authors: Suchandan Sikder, Georgina Price, Md Abdul Alim, Anil Gautam, Robert Scott Simpson, Catherine Margaret Rush, Brenda Lee Govan, Natkunam Ketheesan
Format: Article
Language:English
Published: Taylor & Francis Group 2019-02-01
Series:Autoimmunity
Subjects:
rheumatic heart disease
group a streptococcus
lewis rat
experimental carditis
adoptive transfer
Online Access:http://dx.doi.org/10.1080/08916934.2019.1605356

Internet

http://dx.doi.org/10.1080/08916934.2019.1605356

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