Group A streptococcal M-protein specific antibodies and T-cells drive the pathology observed in the rat autoimmune valvulitis model
Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are autoimmune mediated diseases triggered by group A streptococcal (GAS) infections. Molecular mimicry between GAS M-proteins and host tissue proteins has been proposed as the mechanism that initiates autoreactive immune responses in ARF...
Main Authors: | Suchandan Sikder, Georgina Price, Md Abdul Alim, Anil Gautam, Robert Scott Simpson, Catherine Margaret Rush, Brenda Lee Govan, Natkunam Ketheesan |
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Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2019-02-01
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Series: | Autoimmunity |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/08916934.2019.1605356 |
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