A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes

A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes

Reactive microglia are observed with aging and in Lewy body disorders, including within the olfactory bulb of men with Parkinson's disease. However, the functional impact of microglia in these disorders is still debated. Resetting these reactive cells by a brief dietary pulse of the colony-stim...

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Bibliographic Details
Main Authors: Tarun N. Bhatia, Anuj S. Jamenis, Muslim Abbas, Rachel N. Clark, Kristin M. Miner, Manisha N. Chandwani, Roxanne E. Kim, William Hilinski, Lauren A. O'Donnell, Kelvin C. Luk, Yejie Shi, Xiaoming Hu, Jun Chen, Jeffrey L. Brodsky, Rehana K. Leak
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Neurobiology of Disease
Subjects:
Microglia
Lewy body
Synuclein
Dementia
Neurodegeneration
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002115

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http://www.sciencedirect.com/science/article/pii/S0969996123002115

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