Development and Characterization of Novel Selective, Non-Basic Dopamine D<sub>2</sub> Receptor Antagonists for the Treatment of Schizophrenia

Development and Characterization of Novel Selective, Non-Basic Dopamine D<sub>2</sub> Receptor Antagonists for the Treatment of Schizophrenia

The dopamine D<sub>2</sub> receptor, which belongs to the family of G protein-coupled receptors (GPCR), is an important and well-validated drug target in the field of medicinal chemistry due to its wide distribution, particularly in the central nervous system, and involvement in the path...

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Bibliographic Details
Main Authors: Piotr Stępnicki, Sylwia Wośko, Agata Bartyzel, Agata Zięba, Damian Bartuzi, Klaudia Szałaj, Tomasz M. Wróbel, Emilia Fornal, Jens Carlsson, Ewa Kędzierska, Ewa Poleszak, Marián Castro, Agnieszka A. Kaczor
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
antipsychotic
dopamine D<sub>2</sub> receptor
schizophrenia
SAR studies
GPCRs
lead optimization
Online Access:https://www.mdpi.com/1420-3049/28/10/4211

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https://www.mdpi.com/1420-3049/28/10/4211

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