A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models

A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models

Tumor suppressor p53 prevents early death due to cancer development. However, the role of p53 in aging process and longevity has not been well-established. In humans, single nucleotide polymorphism (SNP) with either arginine (R72) or proline (P72) at codon 72 influences p53 activity; the P72 allele...

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Bibliographic Details
Main Authors: Yuhan Zhao, Lihua Wu, Xuetian Yue, Cen Zhang, Jianming Wang, Jun Li, Xiaohui Sun, Yiming Zhu, Zhaohui Feng, Wenwei Hu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
p53
single nucleotide polymorphism
p53 codon 72
aging
stem cells
cancer
Online Access:https://elifesciences.org/articles/34701

Internet

https://elifesciences.org/articles/34701

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