Gene editing for latent herpes simplex virus infection reduces viral load and shedding in vivo

Gene editing for latent herpes simplex virus infection reduces viral load and shedding in vivo

Abstract Anti-HSV therapies are only suppressive because they do not eliminate latent HSV present in ganglionic neurons, the source of recurrent disease. We have developed a potentially curative approach against HSV infection, based on gene editing using HSV-specific meganucleases delivered by adeno...

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Bibliographic Details
Main Authors: Martine Aubert, Anoria K. Haick, Daniel E. Strongin, Lindsay M. Klouser, Michelle A. Loprieno, Laurence Stensland, Tracy K. Santo, Meei-Li Huang, Ollivier Hyrien, Daniel Stone, Keith R. Jerome
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47940-y

Internet

https://doi.org/10.1038/s41467-024-47940-y

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