Gene editing for latent herpes simplex virus infection reduces viral load and shedding in vivo

Gene editing for latent herpes simplex virus infection reduces viral load and shedding in vivo

Abstract Anti-HSV therapies are only suppressive because they do not eliminate latent HSV present in ganglionic neurons, the source of recurrent disease. We have developed a potentially curative approach against HSV infection, based on gene editing using HSV-specific meganucleases delivered by adeno...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän: Martine Aubert, Anoria K. Haick, Daniel E. Strongin, Lindsay M. Klouser, Michelle A. Loprieno, Laurence Stensland, Tracy K. Santo, Meei-Li Huang, Ollivier Hyrien, Daniel Stone, Keith R. Jerome
Materialtyp: Artikel
Språk:English
Publicerad: Nature Portfolio 2024-05-01
Serie:Nature Communications
Länkar:https://doi.org/10.1038/s41467-024-47940-y

Internet

https://doi.org/10.1038/s41467-024-47940-y

Liknande verk