In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis

In Silico Drug Discovery Strategies Identified ADMET Properties of Decoquinate RMB041 and Its Potential Drug Targets against Mycobacterium tuberculosis

ABSTRACT The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics and the high costs for clinical trials, hampers the development of novel antimicrobial agents with improved efficacy and safety. Subsequently, in silico drug screening methods are more commonly being...

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Bibliographic Details
Main Authors: Kirsten E. Knoll, Mietha M. van der Walt, Du Toit Loots
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
in silico
decoquinate RMB041
virtual docking
Mycobacterium tuberculosis
pharmacokinetics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02315-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.02315-21

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