Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle

Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle

Summary: Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed to affect gene regulation. Gene expression and RNA splicing are primary steps of transcription, so DNA variants changing gene expression (eVariants) or RNA splicing (sVariants) are expected to signifi...

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Bibliographic Details
Main Authors: Ruidong Xiang, Lingzhao Fang, Shuli Liu, Iona M. Macleod, Zhiqian Liu, Edmond J. Breen, Yahui Gao, George E. Liu, Albert Tenesa, Brett A. Mason, Amanda J. Chamberlain, Naomi R. Wray, Michael E. Goddard
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Genomics
Subjects:
gene expression
RNA splicing
eQTL
sQTL
complex traits
heritability
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X23001829

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http://www.sciencedirect.com/science/article/pii/S2666979X23001829

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