Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

Focal disturbances in the blood–brain barrier are associated with formation of neuroinflammatory lesions

Early changes in the normal appearing white matter of multiple sclerosis (MS) patients precede the appearance of gadolinium-enhancing lesions. Although these findings suggest blood–brain barrier (BBB) breakdown as an important feature in MS pathogenesis, limited information is available on the BBB a...

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Bibliographic Details
Main Authors: Jorge Ivan Alvarez, Olivia Saint-Laurent, Alisha Godschalk, Simone Terouz, Casper Briels, Sandra Larouche, Lyne Bourbonnière, Catherine Larochelle, Alexandre Prat
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Blood–brain barrier
Multiple sclerosis
Lesion
Tight junctions
Adherens junctions
EAE
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114002885

Internet

http://www.sciencedirect.com/science/article/pii/S0969996114002885

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