Senescent cardiac fibroblast is critical for cardiac fibrosis after myocardial infarction.

Senescence is a recognized mechanism of cardiovascular diseases; however, its contribution to myocardial fibrosis and rupture after infarction and the underlying mechanisms remain unclear. Here we showed that senescent cardiac fibroblasts markedly accumulated in heart after myocardial infarction. Th...

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Bibliographic Details
Main Authors: Fuli Zhu, Yulin Li, Junmeng Zhang, Chunmei Piao, Tingting Liu, Hui-Hua Li, Jie Du
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3770549?pdf=render