Preclinical Evaluation of [68Ga]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors

Preclinical Evaluation of [68Ga]Ga-DFO-ZEGFR:2377: A Promising Affibody-Based Probe for Noninvasive PET Imaging of EGFR Expression in Tumors

Radionuclide imaging of epidermal growth factor receptor (EGFR) expression in tumors may stratify patients for EGFR-targeting therapies and predict response or resistance to certain treatments. Affibody molecules, which are nonimmunoglobulin scaffold proteins, have a high potential as probes for mol...

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Bibliographic Details
Main Authors: Maryam Oroujeni, Javad Garousi, Ken G. Andersson, John Löfblom, Bogdan Mitran, Anna Orlova, Vladimir Tolmachev
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cells
Subjects:
EGFR
radionuclide imaging
PET
affibody molecules
Ga-68
Zr-89
DFO
nude mice
A431 xenografts
Online Access:http://www.mdpi.com/2073-4409/7/9/141

Internet

http://www.mdpi.com/2073-4409/7/9/141

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