A method of large DNA fragment enrichment for nanopore sequencing in region 22q11.2

Background: 22q11.2 deletion syndrome (22q11.2DS) is a disorder caused when a small part of chromosome 22 is missing. Diagnosis is currently established by the identification of a heterozygous deletion at chromosome 22q11.2 through chromosomal microarray analysis or other genomic analyses. However,...

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Bibliographic Details
Main Authors: Yu-Qing Lei, Liang-Pu Xu, Hua Cao, Xin-Rui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.959883/full