AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN
Abstract Background Both the 7th and 8th editions of the American Joint Committee on Cancer (AJCC) staging systems have been introduced for pancreatic adenocarcinoma. However, the applicability of these classifications for invasive intraductal papillary mucinous neoplasms (IPMN) has not been systema...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | http://link.springer.com/article/10.1186/s12957-019-1682-9 |
| _version_ | 1828778517519663104 |
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| author | Zhiyao Fan He Cheng Kaizhou Jin Yitao Gong Qiuyi Huang Jin Xu Quanxing Ni Xianjun Yu Chen Liu Guopei Luo |
| author_facet | Zhiyao Fan He Cheng Kaizhou Jin Yitao Gong Qiuyi Huang Jin Xu Quanxing Ni Xianjun Yu Chen Liu Guopei Luo |
| author_sort | Zhiyao Fan |
| collection | DOAJ |
| description | Abstract Background Both the 7th and 8th editions of the American Joint Committee on Cancer (AJCC) staging systems have been introduced for pancreatic adenocarcinoma. However, the applicability of these classifications for invasive intraductal papillary mucinous neoplasms (IPMN) has not been systematically examined. Methods Patients with invasive IPMN were retrieved from a cohort of 18 geographical sites (1973–2014 varying) in the Surveillance, Epidemiology, and End Results (SEER) cancer registry. The 7th and 8th editions of the AJCC staging were compared. Survival rates and multivariate analyses were computed. Results In total, 1216 patients with resected invasive IPMN were included. A major difference between the 7th and 8th systems is the definition of stage IIA (7th, beyond the pancreas without involvement of major arteries; 8th, maximum tumor diameter > 4 cm). The hazard ratio (HR) of stage IIA disease (versus stage IA, HR = 2.33, P < 0.001) was higher than that of stage IB disease (HR = 1.48, P = 0.087) by the 7th edition classification, whereas the HR of stage IIA disease (HR = 1.26, P = 0.232) was even lower than that of stage IB disease (HR = 1.48, P = 0.040) by the 8th edition classification. In addition, for the 8th edition staging system, tumor size was not a predictor of survival in patients with resectable tumor > 2 cm (size > 4 cm versus > 2 ≤ 4 cm, HR = 0.91, P = 0.420). Conclusions The AJCC 7th edition staging classification is more applicable than the 8th edition classification for invasive IPMN. |
| first_indexed | 2024-12-11T16:43:59Z |
| format | Article |
| id | doaj.art-973196a123634d8faaafc1db77eeb53e |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-11T16:43:59Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-973196a123634d8faaafc1db77eeb53e2022-12-22T00:58:16ZengBMCWorld Journal of Surgical Oncology1477-78192019-08-011711810.1186/s12957-019-1682-9AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMNZhiyao Fan0He Cheng1Kaizhou Jin2Yitao Gong3Qiuyi Huang4Jin Xu5Quanxing Ni6Xianjun Yu7Chen Liu8Guopei Luo9Department of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer CenterAbstract Background Both the 7th and 8th editions of the American Joint Committee on Cancer (AJCC) staging systems have been introduced for pancreatic adenocarcinoma. However, the applicability of these classifications for invasive intraductal papillary mucinous neoplasms (IPMN) has not been systematically examined. Methods Patients with invasive IPMN were retrieved from a cohort of 18 geographical sites (1973–2014 varying) in the Surveillance, Epidemiology, and End Results (SEER) cancer registry. The 7th and 8th editions of the AJCC staging were compared. Survival rates and multivariate analyses were computed. Results In total, 1216 patients with resected invasive IPMN were included. A major difference between the 7th and 8th systems is the definition of stage IIA (7th, beyond the pancreas without involvement of major arteries; 8th, maximum tumor diameter > 4 cm). The hazard ratio (HR) of stage IIA disease (versus stage IA, HR = 2.33, P < 0.001) was higher than that of stage IB disease (HR = 1.48, P = 0.087) by the 7th edition classification, whereas the HR of stage IIA disease (HR = 1.26, P = 0.232) was even lower than that of stage IB disease (HR = 1.48, P = 0.040) by the 8th edition classification. In addition, for the 8th edition staging system, tumor size was not a predictor of survival in patients with resectable tumor > 2 cm (size > 4 cm versus > 2 ≤ 4 cm, HR = 0.91, P = 0.420). Conclusions The AJCC 7th edition staging classification is more applicable than the 8th edition classification for invasive IPMN.http://link.springer.com/article/10.1186/s12957-019-1682-9Intraductal papillary mucinous neoplasmStageTNMPrognosisAmerican Joint Committee on Cancer |
| spellingShingle | Zhiyao Fan He Cheng Kaizhou Jin Yitao Gong Qiuyi Huang Jin Xu Quanxing Ni Xianjun Yu Chen Liu Guopei Luo AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN World Journal of Surgical Oncology Intraductal papillary mucinous neoplasm Stage TNM Prognosis American Joint Committee on Cancer |
| title | AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN |
| title_full | AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN |
| title_fullStr | AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN |
| title_full_unstemmed | AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN |
| title_short | AJCC 7th edition staging classification is more applicable than AJCC 8th edition staging classification for invasive IPMN |
| title_sort | ajcc 7th edition staging classification is more applicable than ajcc 8th edition staging classification for invasive ipmn |
| topic | Intraductal papillary mucinous neoplasm Stage TNM Prognosis American Joint Committee on Cancer |
| url | http://link.springer.com/article/10.1186/s12957-019-1682-9 |
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