The Antithrombotic Agent Pterostilbene Interferes with Integrin α<sub>IIb</sub>β<sub>3</sub>-Mediated Inside-Out and Outside-In Signals in Human Platelets

The Antithrombotic Agent Pterostilbene Interferes with Integrin α<sub>IIb</sub>β<sub>3</sub>-Mediated Inside-Out and Outside-In Signals in Human Platelets

Platelets play a crucial role in the physiology of primary hemostasis and pathological processes such as arterial thrombosis; thus, developing a therapeutic target that prevents platelet activation can reduce arterial thrombosis. Pterostilbene (PTE) has remarkable pharmacological activities, includi...

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Bibliographic Details
Main Authors: Wei-Chieh Huang, Kao-Chang Lin, Chih-Wei Hsia, Chih-Hsuan Hsia, Ting-Yu Chen, Periyakali Saravana Bhavan, Joen-Rong Sheu, Shaw-Min Hou
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
arterial thrombosis
hydroxyl radicals
integrin α<sub>IIb</sub>β<sub>3</sub>
platelet aggregation
pterostilbene
resveratrol derivative
Online Access:https://www.mdpi.com/1422-0067/22/7/3643

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https://www.mdpi.com/1422-0067/22/7/3643

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