Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear Cells
Abstract.: We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and sp...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2006-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319344536 |
| _version_ | 1819079852944261120 |
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| author | Miura Ryuzea Nakamura Kazufumi Miura Daiji Miura Aya Hisamatsu Kenichi Kajiya Masahito Nagase Satoshi Morita Hiroshi Kusano Kengo Fukushima Ohe Tohru Ishihara Kazuhiko |
| author_facet | Miura Ryuzea Nakamura Kazufumi Miura Daiji Miura Aya Hisamatsu Kenichi Kajiya Masahito Nagase Satoshi Morita Hiroshi Kusano Kengo Fukushima Ohe Tohru Ishihara Kazuhiko |
| author_sort | Miura Ryuzea |
| collection | DOAJ |
| description | Abstract.: We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-α induced by exogenous Ang II. Specifically, 10 µM of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required. Keywords:: spironolactone, angiotensin II, peripheral blood mononuclear cell |
| first_indexed | 2024-12-21T19:35:35Z |
| format | Article |
| id | doaj.art-9734ee702fb640b19be7e01102502a99 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-21T19:35:35Z |
| publishDate | 2006-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-9734ee702fb640b19be7e01102502a992022-12-21T18:52:36ZengElsevierJournal of Pharmacological Sciences1347-86132006-01-011013256259Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear CellsMiura Ryuzea0Nakamura Kazufumi1Miura Daiji2Miura Aya3Hisamatsu Kenichi4Kajiya Masahito5Nagase Satoshi6Morita Hiroshi7Kusano Kengo Fukushima8Ohe Tohru9Ishihara Kazuhiko10Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan; Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan; Corresponding author (affiliation #2). miura@mpc.t.u-tokyo.ac.jpDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, JapanDepartment of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, JapanAbstract.: We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-α) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-α induced by exogenous Ang II. Specifically, 10 µM of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required. Keywords:: spironolactone, angiotensin II, peripheral blood mononuclear cellhttp://www.sciencedirect.com/science/article/pii/S1347861319344536 |
| spellingShingle | Miura Ryuzea Nakamura Kazufumi Miura Daiji Miura Aya Hisamatsu Kenichi Kajiya Masahito Nagase Satoshi Morita Hiroshi Kusano Kengo Fukushima Ohe Tohru Ishihara Kazuhiko Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear Cells Journal of Pharmacological Sciences |
| title | Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear Cells |
| title_full | Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear Cells |
| title_fullStr | Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear Cells |
| title_full_unstemmed | Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear Cells |
| title_short | Anti-inflammatory Effect of Spironolactone on Human Peripheral Blood Mononuclear Cells |
| title_sort | anti inflammatory effect of spironolactone on human peripheral blood mononuclear cells |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319344536 |
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