Angiopoietin‐2 Promotes Mechanical Stress‐induced Extracellular Matrix Degradation in Annulus Fibrosus Via the HIF‐1α/NF‐κB Signaling Pathway

Angiopoietin‐2 Promotes Mechanical Stress‐induced Extracellular Matrix Degradation in Annulus Fibrosus Via the HIF‐1α/NF‐κB Signaling Pathway

Objective Mechanical stress is an important risk factor for intervertebral disc degeneration (IVDD). Angiopoietin‐2 (ANG‐2) is regulated by mechanical stress and is widely involved in the regulation of extracellular matrix metabolism. In addition, the signaling cascade between HIF‐1α and NF‐κB is cr...

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Bibliographic Details
Main Authors: Xiang Ao, Yuan Li, Tao Jiang, Chenglong Li, Zhengnan Lian, Liang Wang, Zhongmin Zhang, Minjun Huang
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Orthopaedic Surgery
Subjects:
Angiopoietin‐2
Annulus fibrosus
HIF‐1α/NF‐κB signaling pathway
Intervertebral disc degeneration
Mechanical stress
Online Access:https://doi.org/10.1111/os.13797

Internet

https://doi.org/10.1111/os.13797

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