Differential binding of tenofovir and adefovir to reverse transcriptase of hepatitis B virus.

Resistance of the reverse transcriptase (RT) of hepatitis B virus (HBV) to the tenofovir nucleotide drug has not been observed since its introduction for treatment of hepatitis B virus (HBV) infection in 2008. In contrast, frequent viral breakthrough and resistance has been documented for adefovir....

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Bibliographic Details
Main Authors: Formijn J van Hemert, Ben Berkhout, Hans L Zaaijer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4152281?pdf=render