Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles

Protection and Systemic Translocation of siRNA Following Oral Administration of Chitosan/siRNA Nanoparticles

Harnessing the RNA interference pathway offers a new therapeutic modality; however, solutions to overcome biological barriers to small interfering RNA (siRNA) delivery are required for clinical translation. This work demonstrates, by direct northern and quantitative PCR (qPCR) detection, stability,...

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Bibliographic Details
Main Authors: Borja Ballarín-González, Frederik Dagnaes-Hansen, Robert A Fenton, Shan Gao, San Hein, Mingdong Dong, Jørgen Kjems, Kenneth A Howard
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
chitosan
mucosal
nanoparticles
oral
siRNA
stability
systemic translocation
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301366

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http://www.sciencedirect.com/science/article/pii/S2162253116301366

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