Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas

Synthesis of 2,2-difluoro-1,3-diketone and 2,2-difluoro-1,3-ketoester derivatives using fluorine gas

Solutions of 1,3-diketones and 1,3-ketoester derivatives react with fluorine to give the corresponding 2,2-difluoro-1,3-dicarbonyl derivatives in the presence of quinuclidine. Quinuclidine reacts with fluorine in situ to generate a fluoride ion that facilitates limiting enolization processes, and an...

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Bibliographic Details
Main Authors: Alexander S. Hampton, David R. W. Hodgson, Graham McDougald, Linhua Wang, Graham Sandford
Format: Article
Language:English
Published: Beilstein-Institut 2024-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
difluorination
difluoromethylene
direct fluorination
electrophilic fluorination
organofluorine
Online Access:https://doi.org/10.3762/bjoc.20.41

Internet

https://doi.org/10.3762/bjoc.20.41

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