Integrated single-cell and bulk RNA sequencing analysis identifies a cancer-associated fibroblast-related gene signature for predicting survival and therapy in gastric cancer

Integrated single-cell and bulk RNA sequencing analysis identifies a cancer-associated fibroblast-related gene signature for predicting survival and therapy in gastric cancer

Abstract As the dominant component of the tumor microenvironment, cancer-associated fibroblasts (CAFs), play a vital role in tumor progression. An increasing number of studies have confirmed that CAFs are involved in almost every aspect of tumors including tumorigenesis, metabolism, invasion, metast...

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Bibliographic Details
Main Authors: Zhiyang Zhou, Sixuan Guo, Shuhui Lai, Tao Wang, Yao Du, Junping Deng, Shun Zhang, Ge Gao, Jiangnan Zhang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Cancer
Subjects:
Cancer-associated fibroblasts
Gastric cancer
Single-cell RNA sequencing
Gene signature
Small molecular drug
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12885-022-10332-w

Internet

https://doi.org/10.1186/s12885-022-10332-w

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