Normalizing JMJD6 Expression in Rat Spinal Dorsal Horn Alleviates Hyperalgesia Following Chronic Constriction Injury

Normalizing JMJD6 Expression in Rat Spinal Dorsal Horn Alleviates Hyperalgesia Following Chronic Constriction Injury

Jumonji domain-containing protein 6 (JMJD6) is a homolog of hypoxia-inducible factor (HIF) asparaginyl hydroxylase, an inhibitor of HIF. HIF-1α is known to participate in neuropathic pain (NPP) during chronic constriction injury (CCI); however, the roles of JMJD6 in NPP have not been systematically...

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Bibliographic Details
Main Authors: Cheng Mo, Mengyuan Xu, Cen Wen, Ruimin Chang, Changsheng Huang, Wangyuan Zou, Xiaoyan Zhu, Qulian Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
JMJD6
HIF-1α
chronic constriction injury
neuropathic pain
caspase-3
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00542/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00542/full

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