AKT isoform-specific expression and activation across cancer lineages

AKT isoform-specific expression and activation across cancer lineages

Abstract Background Aberrant AKT activation is prevalent across human cancer lineages, providing an important therapeutic target. AKT comprises three isoforms that mediate critical non-redundant, even opposing functions in cancer pathophysiology. Therefore, targeting specific AKT isoforms in particu...

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Bibliographic Details
Main Authors: Jue Wang, Wei Zhao, Huifang Guo, Yong Fang, Sarah Elizabeth Stockman, Shanshan Bai, Patrick Kwok-Shing Ng, Yang Li, Qinghua Yu, Yiling Lu, Kang Jin Jeong, Xiaohua Chen, Meng Gao, Jiyong Liang, Wentao Li, Xingsong Tian, Eric Jonasch, Gordon B. Mills, Zhiyong Ding
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Cancer
Subjects:
AKT
Isoform
Expression
Phosphorylation
Activation
RPPA
Online Access:http://link.springer.com/article/10.1186/s12885-018-4654-5

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http://link.springer.com/article/10.1186/s12885-018-4654-5

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