3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

3,1-Benzothiazines, 1,4-Benzodioxines and 1,4-Benzoxazines as Inhibitors of Matriptase-2: Outcome of a Focused Screening Approach

The liver enzyme matriptase-2 is a multi-domain, transmembrane serine protease with an extracellular, C-terminal catalytic domain. Synthetic low-molecular weight inhibitors of matriptase-2 have potential as therapeutics to treat iron overload syndromes, in particular in patients with β-thalassemia....

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Bibliographic Details
Main Authors: Polya G. Roydeva, Anna-Madeleine Beckmann, Marit Stirnberg, Jožko Cesar, Danijel Kikelj, Janez Ilaš, Michael Gütschow
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:Pharmaceuticals
Subjects:
benzamidines
4H-3,1-benzothiazin-4-ones
2,3-dihydro-1,4-benzodioxines
3,4-dihydro-2H-1,4-benzoxazines
matriptase-2
protease inhibition
Online Access:http://www.mdpi.com/1424-8247/9/1/2

Internet

http://www.mdpi.com/1424-8247/9/1/2

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