Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task

Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task

The locus coeruleus (LC) is the sole source of noradrenergic projections to the cortex and essential for attention-dependent cognitive processes. In this study we used unilateral optogenetic silencing of the LC in an attentional set-shifting task (ASST) to evaluate the influence of the LC on prefron...

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Bibliographic Details
Main Authors: Kathrin eJanitzky, Michael eLippert, Achim eEngelhorn, Jürgen eGoldschmidt, Jennifer eTegtmeier, Hans-Jochen eHeinze, Frank W. Ohl
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Locus Coeruleus
Prefrontal Cortex
optogenetics
halorhodopsin
cognitive flexibility
B6.Cg-Tg(Th-cre)1Tmd/J hemizygous mice
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00286/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00286/full

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